Ultraconserved Elements in the Olig2 Promoter
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چکیده
منابع مشابه
Ultraconserved Elements in the Olig2 Promoter
BACKGROUND Oligodendrocytes are specialized cells of the nervous system that produce the myelin sheaths surrounding the axons of neurons. Myelinating the axons increases the speed of nerve conduction and demyelination contributes to the pathology of neurodegenerative diseases such as multiple sclerosis. Oligodendrocyte differentiation is specified early in development by the expression of the b...
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Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It ...
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Ultraconserved elements have been suggested to retain extended perfect sequence identity between the human, mouse, and rat genomes due to essential functional properties. To investigate the necessities of these elements in vivo, we removed four noncoding ultraconserved elements (ranging in length from 222 to 731 base pairs) from the mouse genome. To maximize the likelihood of observing a phenot...
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1839 With over 180 genomes sequenced to date and counting, researchers must rely on certain assumptions to help them sift through mountains of data and identify the most promising candidates for functional analysis. One of the guiding principles of comparative genome analysis assumes that highly conserved DNA sequences—which show little variation across species—have been preserved throughout ev...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0003946